Dimerization in protein kinase signaling
نویسنده
چکیده
The closely related mitogen-activated protein kinases ERK1 and ERK2 have now been shown to have opposing roles in Ras-mediated cell proliferation. I propose that dimerization of these highly related protein kinases could underlie these surprising observations and that this could be a common paradigm for widespread regulation of protein phosphorylation by kinase-substrate interactions.
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ورودعنوان ژورنال:
- Journal of Biology
دوره 5 شماره
صفحات -
تاریخ انتشار 2006